Process design and techno-economic analysis of 2′-fucosyllactose enriched distiller’s dried grains with solubles production in dry grind ethanol process using genetically engineered Saccharomyces cerevisiae

2′-fucosyllactose (2′-FL) has been linked positively with piglet gut health. Genetically engineered Saccharomyces cerevisiae strains producing 2′-FL can be used in the dry grind process to enrich Distiller’s dried grains solubles (DDGS) and supplement swine diets 2′-FL. The objectives of our study were modify ethanol for enriched DDGS production evaluate techno-economic feasibility process. Concentrations 19.8 g 2′-FL/kg achieved using strain without negatively affecting yield. Process models conventional modified processes (1150 MT corn/day capacity) developed SuperPro Designer. Capital costs higher than internal rate return was $300/MT selling price.